Search | Virtual Health Library

1.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Brown, Nicholas G; VanderLinden, Ryan; Watson, Edmond R; Weissmann, Florian; Ordureau, Alban; Wu, Kuen-Phon; Zhang, Wei; Yu, Shanshan; Mercredi, Peter Y; Harrison, Joseph S; Davidson, Iain F; Qiao, Renping; Lu, Ying; Dube, Prakash; Brunner, Michael R; Grace, Christy R R; Miller, Darcie J; Haselbach, David; Jarvis, Marc A; Yamaguchi, Masaya; Yanishevski, David; Petzold, Georg; Sidhu, Sachdev S; Kuhlman, Brian; Kirschner, Marc W; Harper, J Wade; Peters, Jan-Michael; Stark, Holger; Schulman, Brenda A.

Cell ; 165(6): 1440-1453, 2016 Jun 02.

Article in English | MEDLINE | ID: mdl-27259151

2.

APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.

Ferguson, Cole J; Urso, Olivia; Bodrug, Tatyana; Gassaway, Brandon M; Watson, Edmond R; Prabu, Jesuraj R; Lara-Gonzalez, Pablo; Martinez-Chacin, Raquel C; Wu, Dennis Y; Brigatti, Karlla W; Puffenberger, Erik G; Taylor, Cora M; Haas-Givler, Barbara; Jinks, Robert N; Strauss, Kevin A; Desai, Arshad; Gabel, Harrison W; Gygi, Steven P; Schulman, Brenda A; Brown, Nicholas G; Bonni, Azad.

Mol Cell ; 82(1): 90-105.e13, 2022 01 06.

Article in English | MEDLINE | ID: mdl-34942119

3.

Gene expression and cell identity controlled by anaphase-promoting complex.

Oh, Eugene; Mark, Kevin G; Mocciaro, Annamaria; Watson, Edmond R; Prabu, J Rajan; Cha, Denny D; Kampmann, Martin; Gamarra, Nathan; Zhou, Coral Y; Rape, Michael.

Nature ; 579(7797): 136-140, 2020 03.

Article in English | MEDLINE | ID: mdl-32076268

4.

Allosteric differences dictate GroEL complementation of E. coli.

Sivinski, Jared; Ngo, Duc; Zerio, Christopher J; Ambrose, Andrew J; Watson, Edmond R; Kaneko, Lynn K; Kostelic, Marius M; Stevens, Mckayla; Ray, Anne-Marie; Park, Yangshin; Wu, Chunxiang; Marty, Michael T; Hoang, Quyen Q; Zhang, Donna D; Lander, Gabriel C; Johnson, Steven M; Chapman, Eli.

FASEB J ; 36(3): e22198, 2022 03.

Article in English | MEDLINE | ID: mdl-35199390

5.

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Brown, Nicholas G; Watson, Edmond R; Weissmann, Florian; Jarvis, Marc A; VanderLinden, Ryan; Grace, Christy R R; Frye, Jeremiah J; Qiao, Renping; Dube, Prakash; Petzold, Georg; Cho, Shein Ei; Alsharif, Omar; Bao, Ju; Davidson, Iain F; Zheng, Jie J; Nourse, Amanda; Kurinov, Igor; Peters, Jan-Michael; Stark, Holger; Schulman, Brenda A.

Mol Cell ; 56(2): 246-260, 2014 Oct 23.

Article in English | MEDLINE | ID: mdl-25306923

6.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Watson, Edmond R; Grace, Christy R R; Zhang, Wei; Miller, Darcie J; Davidson, Iain F; Prabu, J Rajan; Yu, Shanshan; Bolhuis, Derek L; Kulko, Elizaveta T; Vollrath, Ronnald; Haselbach, David; Stark, Holger; Peters, Jan-Michael; Brown, Nicholas G; Sidhu, Sachdev S; Schulman, Brenda A.

Proc Natl Acad Sci U S A ; 116(35): 17280-17289, 2019 08 27.

Article in English | MEDLINE | ID: mdl-31350353

7.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Brown, Nicholas G; VanderLinden, Ryan; Watson, Edmond R; Qiao, Renping; Grace, Christy R R; Yamaguchi, Masaya; Weissmann, Florian; Frye, Jeremiah J; Dube, Prakash; Ei Cho, Shein; Actis, Marcelo L; Rodrigues, Patrick; Fujii, Naoaki; Peters, Jan-Michael; Stark, Holger; Schulman, Brenda A.

Proc Natl Acad Sci U S A ; 112(17): 5272-9, 2015 Apr 28.

Article in English | MEDLINE | ID: mdl-25825779

8.

Molecular glue CELMoD compounds are regulators of cereblon conformation.

Watson, Edmond R; Novick, Scott; Matyskiela, Mary E; Chamberlain, Philip P; H de la Peña, Andres; Zhu, Jinyi; Tran, Eileen; Griffin, Patrick R; Wertz, Ingrid E; Lander, Gabriel C.

Science ; 378(6619): 549-553, 2022 11 04.

Article in English | MEDLINE | ID: mdl-36378961

9.

Complex interactions of Tyrp1 in the eye.

Lu, Hong; Li, Liyuan; Watson, Edmond R; Williams, Robert W; Geisert, Eldon E; Jablonski, Monica M; Lu, Lu.

Mol Vis ; 17: 2455-68, 2011.

Article in English | MEDLINE | ID: mdl-21976956

10.

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.

Shin, Mia; Watson, Edmond R; Song, Albert S; Mindrebo, Jeffrey T; Novick, Scott J; Griffin, Patrick R; Wiseman, R Luke; Lander, Gabriel C.

Nat Commun ; 12(1): 3239, 2021 05 28.

Article in English | MEDLINE | ID: mdl-34050165

11.

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.

Watson, Edmond R; Brown, Nicholas G; Peters, Jan-Michael; Stark, Holger; Schulman, Brenda A.

Trends Cell Biol ; 29(2): 117-134, 2019 02.

Article in English | MEDLINE | ID: mdl-30482618

12.

Measuring APC/C-Dependent Ubiquitylation In Vitro.

Jarvis, Marc A; Brown, Nicholas G; Watson, Edmond R; VanderLinden, Ryan; Schulman, Brenda A; Peters, Jan-Michael.

Methods Mol Biol ; 1342: 287-303, 2016.

Article in English | MEDLINE | ID: mdl-26254932

13.

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.

Pierce, Wendy K; Grace, Christy R; Lee, Jihun; Nourse, Amanda; Marzahn, Melissa R; Watson, Edmond R; High, Anthony A; Peng, Junmin; Schulman, Brenda A; Mittag, Tanja.

J Mol Biol ; 428(6): 1256-1271, 2016 Mar 27.

Article in English | MEDLINE | ID: mdl-26475525

14.

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.

Li, Guoqiang; Ci, Weimin; Karmakar, Subhradip; Chen, Ke; Dhar, Ruby; Fan, Zhixiang; Guo, Zhongqiang; Zhang, Jing; Ke, Yuwen; Wang, Lu; Zhuang, Min; Hu, Shengdi; Li, Xuesong; Zhou, Liqun; Li, Xianghong; Calabrese, Matthew F; Watson, Edmond R; Prasad, Sandip M; Rinker-Schaeffer, Carrie; Eggener, Scott E; Stricker, Thomas; Tian, Yong; Schulman, Brenda A; Liu, Jiang; White, Kevin P.

Cancer Cell ; 25(4): 455-68, 2014 Apr 14.

Article in English | MEDLINE | ID: mdl-24656772

15.

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Frye, Jeremiah J; Brown, Nicholas G; Petzold, Georg; Watson, Edmond R; Grace, Christy R R; Nourse, Amanda; Jarvis, Marc A; Kriwacki, Richard W; Peters, Jan-Michael; Stark, Holger; Schulman, Brenda A.

Nat Struct Mol Biol ; 20(7): 827-35, 2013 Jul.

Article in English | MEDLINE | ID: mdl-23708605

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